What is a .MAF File And How To Open It – National Cancer Institute

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Have you downloaded a file with .maf extension, but you are not sure what it is? It is possible that you know what the file does, but you are unsure on how to open it. Thanks to this easy guide you will be able to find out what .maf file extension is, how to open it and how to work with it.

What is a .MAF file?

The file extension .MAF is Mutation Annotation Format File. It was developed by National Cancer Institute. The format of this data related file is text.

What to know

There are currently 2 software that can open the .maf file on 1 platform.

How to open a .MAF file?

In this part of the article we will show you how to open the .MAF file on various operating systems.

How to open a .MAF file on Windows (7, 8, 10)

There are 4 simple steps to open the .maf file on Windows.

1. The first step is to download the Microsoft Notepad and Microsoft WordPad software. You will be using this software in order to open the file.

Step 2

Step 2: Locating your .MAF file

2. The second step is locating the downloaded file. If you don’t remember where you have downloaded your file to, you should check your /download/ folder as it usually gets automatically saved there.

Step 3

Step 3: Choose “Open with”

3. In the third step right click on your file and choose “Open with”.

Step 4

Step 4: Choose the software and click ok

4. After choosing the “Open with” option, you will have an option to choose the Microsoft Notepad software you have downloaded. Choose your software and click on “OK”. Congratulations! You have opened your file on Windows.

Still cannot open the .MAF file?

If you cannot open the .MAF file, it is entirely possible that you are trying to open the wrong file. The .MAF file extension is similar to other file extensions such as: .maf – Microsoft. You might be trying to open one of them. Please recheck the file extension again.


In this article you have learned how to open the .MAF file with the Microsoft Notepad, Microsoft WordPad programs on Windows.